Many men who are transgender who want to convert to the opposite sex consider the usage of estrogen therapy for breast enhancement. But uniformly it is not been effectively because in the same men lot of testosterone is produced. Testosterone overwhelms the ability for androgen to cause breast hypertrophy. Typically if estrogen is administered in a testosterone deficient environment, it might cause breast enlargement or enhancement or if there are androgens floating down, them that suppress the breast development. So approach an endocrinologist if there is breast enhancement required for men. When there are estrogen secreting tumors, you can have concurrently, especially testosterone deficiency and then because of the tumour and estrogen production. So in such situations, you could have spontaneous breast enlargement though these are all very rare tumour that are seen very rarely maybe 1 in a million, very very uncommon tumors.
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